Life under
CANVAS.

The latest research on CANVAS syndrome, in one place — updated automatically, and always here when you need answers.

Latest research

PubMed

Motor, Extrapyramidal, and Cognitive Involvement in RFC1 Disease: A Systematic Review and Meta-Analysis

Massucco S, Hamedani M, Ponzano M et al.

Neurol Genet · 2026 Jun

Comprehensive neuropsychological assessment and FDG-PET imaging in patients with RFC1-related disorder

Delgado-Álvarez A, Gajate-García V, Cabrera-Martín MN et al.

Parkinsonism Relat Disord · 2026 May 20

Neurogenic cough in CANVAS syndrome: objective cough monitoring reveals a distinctive clinical pattern

Crespo-Lessmann A, Bustamante D, Vélez-Segovia E et al.

J Neurol · 2026 Apr 9

Vestibular assessment in definite cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS): A case of siblings study

Matsuda K, Sato G, Takaoka S et al.

Auris Nasus Larynx · 2026 Mar 3

Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment

Storm R, Lübbers B, Borsche M et al.

J Neurol · 2026 Feb 14

Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort

Alm V, Säll L, Samuelsson K et al.

Eur J Neurol · 2026 Feb

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures

Wang J, Qiu D, Zhou J et al.

Nucleic Acids Res · 2026 Jan 22

Repeat Expansions in a Chilean Cohort with Adult-Onset Cerebellar Ataxia

Bustamante ML, Miranda M, Pellerin D et al.

Cerebellum · 2025 Dec 22

Enhancing Cerebellar Findings with Positional Manoeuvres

García CMS, Özdemir HN, Kaski D

Cerebellum · 2025 Nov 4

Nerve ultrasound, neuronopathy and cough predict sensory neuropathy patients with RFC1 expansions

Garvey A, Melville IZ, Scriba CK et al.

Brain Commun · 2025

The Cerebellar Neuropsychiatric Rating Scale in the Spinocerebellar Ataxias

Burt AL, Daly MP, Sherman JC et al.

Cerebellum · 2025 May 5

The Spectrum of Peripheral-Vestibular Deficits and Their Change Over Time in CANVAS/RFC1-Related Ataxia Systematic Review and Meta-Analysis of Quantitative Head-Impulse Testing

Szymanska Heydel M, Heindl F, Hartmann A et al.

Cerebellum · 2025 Mar 20

Latest research

PubMed

In the news

Google News

CANVAS as example of genetic and clinical complexity of RFC1 -related disorders - Via Medica Journals

Via Medica Journals

4 Oct 2025

Elucidating the pathobiology of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) with its expanded RNA structure formation and proteinopathy - Nature

Nature

14 Nov 2024

Prevalence of RFC1 -mediated spinocerebellar ataxia in a North American ataxia cohort - Neurology® Journals

Neurology® Journals

10 Dec 2023

Q&A: Fay Grant On Bringing Her Entrepreneur Spirit To Fighting RFC1-CANVAS - Forbes

Forbes

2 Jun 2023

Biallelic expansion in RFC1 as a rare cause of Parkinson’s disease - Nature

Nature

10 Jan 2022

An Unusual Mutation Type Explains the Nature of Late-Life Balance Problems - University of Miami

University of Miami

11 Apr 2019

Profiling complex repeat expansions in RFC1 in Parkinson’s disease - Nature

Nature

24 May 2024

Long-read sequencing revealed complex biallelic pentanucleotide repeat expansions in RFC1 -related Parkinson’s disease - Nature

Nature

20 Jan 2025

From Ataxia UK

ataxia.org.uk

Why me?

Ataxia UK

21 May 2026

An update on genetic testing in ataxia

Ataxia UK

13 May 2026

Drug Repurposing to Accelerate Therapeutic Development for ITPR1-Associated Cerebellar Ataxias

Ataxia UK

11 May 2026

Design Therapeutics RESTORE-FA trial updates page

Ataxia UK

29 Apr 2026

Vitamin D levels and Friedreich's ataxia

Ataxia UK

29 Apr 2026

Family by Clare Sheeran

Ataxia UK

20 Apr 2026

Towards improved mental quality of life in ataxias: Characterising psychological function and its correlates

Ataxia UK

17 Apr 2026

Lexeo Therapeutics update page

Ataxia UK

14 Apr 2026

From Euro Ataxia

euroataxia.org

Using the SPAX mobile app for measuring symptom progression in the home in spastic ataxias

Euro Ataxia

19 Feb 2026

New paper published on the feasibility and validity of the Goal Attainment Scale to measure treatment effectiveness in people with SCA3

Euro Ataxia

4 Dec 2025

Reflections on the 2025 Euro-ataxia conference

Euro Ataxia

12 Nov 2025

Lexeo shares positive data in trial of LX2006 for FA cardiomyopathy

Euro Ataxia

9 Oct 2025

Reflections from the International Drug Repurposing Conference 2025

Euro Ataxia

14 May 2025

Paper published comparing specialist ataxia centres with non-specialist services in terms of care, organisation, health services resource utilisation, and costs in Germany

Euro Ataxia

15 Feb 2025

Videos

YouTube

RFC1 ve CANVAS Hastalığı: Sebep, Prognoz, Tedavi ve Gelecek Yaklaşımlar

Ayça Arslan

19 Apr 2026

SÍNDROME DE CANVAS: La tríada de Ataxia, Tos y Genética que debes conocer

MediLu: aprende medicina facil

5 Jan 2026

C.A.N.V.A.S

Neuro-Ophthalmology with Dr. Andrew G. Lee

25 Jul 2025

Neuroscience Grand Rounds, May 2025 | Improving Genetic Diagnosis in Cerebellar Ataxia

Pacific Neuroscience Institute

31 May 2025

CANVAS

ENT surgery lecture by Dr Sunil Kumar Sharma

9 Jan 2025

It Works For Me – Coping with CANVAS, Michele Cunningham

AtaxiaUKonline

31 Oct 2024

Thérapies innovantes pour les ataxies héréditaire- Projet Éric Samarut et Martine Tétreault

ATAXIE - ATAXIA CANADA

29 Mar 2024

Research and Treatment Development for CANVAS

National Ataxia Foundation

19 Feb 2024

Patient community

HealthUnlocked · Ataxia UK

Ataxia UK community

The HealthUnlocked community run by Ataxia UK — questions, lived experience, and peer support from people affected by ataxia.

Join the conversation →

Ataxia UK

The UK's leading ataxia charity. Information on CANVAS, specialist clinics, research funding, and support services.

Visit Ataxia UK →

RFC1 CANVAS Research Group

Research updates from the international clinical and scientific community studying RFC1-related CANVAS syndrome.

View research →

Ask a question

Ask anything about CANVAS syndrome — symptoms, research, daily life, or treatment.

Life underCANVAS.

Latest research

Motor, Extrapyramidal, and Cognitive Involvement in RFC1 Disease: A Systematic Review and Meta-Analysis

Comprehensive neuropsychological assessment and FDG-PET imaging in patients with RFC1-related disorder

Neurogenic cough in CANVAS syndrome: objective cough monitoring reveals a distinctive clinical pattern

Vestibular assessment in definite cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS): A case of siblings study

Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment

Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures

Repeat Expansions in a Chilean Cohort with Adult-Onset Cerebellar Ataxia

Enhancing Cerebellar Findings with Positional Manoeuvres

Nerve ultrasound, neuronopathy and cough predict sensory neuropathy patients with RFC1 expansions

The Cerebellar Neuropsychiatric Rating Scale in the Spinocerebellar Ataxias

The Spectrum of Peripheral-Vestibular Deficits and Their Change Over Time in CANVAS/RFC1-Related Ataxia Systematic Review and Meta-Analysis of Quantitative Head-Impulse Testing

Latest research

In the news

CANVAS as example of genetic and clinical complexity of RFC1 -related disorders - Via Medica Journals

Elucidating the pathobiology of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) with its expanded RNA structure formation and proteinopathy - Nature

Prevalence of RFC1 -mediated spinocerebellar ataxia in a North American ataxia cohort - Neurology® Journals

Q&amp;A: Fay Grant On Bringing Her Entrepreneur Spirit To Fighting RFC1-CANVAS - Forbes

Biallelic expansion in RFC1 as a rare cause of Parkinson’s disease - Nature

An Unusual Mutation Type Explains the Nature of Late-Life Balance Problems - University of Miami

Profiling complex repeat expansions in RFC1 in Parkinson’s disease - Nature

Long-read sequencing revealed complex biallelic pentanucleotide repeat expansions in RFC1 -related Parkinson’s disease - Nature

From Ataxia UK

Why me?

An update on genetic testing in ataxia

Drug Repurposing to Accelerate Therapeutic Development for ITPR1-Associated Cerebellar Ataxias

Design Therapeutics RESTORE-FA trial updates page

Vitamin D levels and Friedreich's ataxia

Family by Clare Sheeran

Towards improved mental quality of life in ataxias: Characterising psychological function and its correlates

Lexeo Therapeutics update page

From Euro Ataxia

Using the SPAX mobile app for measuring symptom progression in the home in spastic ataxias

New paper published on the feasibility and validity of the Goal Attainment Scale to measure treatment effectiveness in people with SCA3

Reflections on the 2025 Euro-ataxia conference

Lexeo shares positive data in trial of LX2006 for FA cardiomyopathy

Reflections from the International Drug Repurposing Conference 2025

Paper published comparing specialist ataxia centres with non-specialist services in terms of care, organisation, health services resource utilisation, and costs in Germany

Videos

RFC1 ve CANVAS Hastalığı: Sebep, Prognoz, Tedavi ve Gelecek Yaklaşımlar

SÍNDROME DE CANVAS: La tríada de Ataxia, Tos y Genética que debes conocer

C.A.N.V.A.S

Neuroscience Grand Rounds, May 2025 | Improving Genetic Diagnosis in Cerebellar Ataxia

CANVAS

It Works For Me – Coping with CANVAS, Michele Cunningham

Thérapies innovantes pour les ataxies héréditaire- Projet Éric Samarut et Martine Tétreault

Research and Treatment Development for CANVAS

Patient community

Ataxia UK community

Ataxia UK

RFC1 CANVAS Research Group

Ask a question

In the news

CANVAS as example of genetic and clinical complexity of RFC1 -related disorders - Via Medica Journals

Elucidating the pathobiology of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) with its expanded RNA structure formation and proteinopathy - Nature

Prevalence of RFC1 -mediated spinocerebellar ataxia in a North American ataxia cohort - Neurology® Journals

Q&amp;A: Fay Grant On Bringing Her Entrepreneur Spirit To Fighting RFC1-CANVAS - Forbes

Biallelic expansion in RFC1 as a rare cause of Parkinson’s disease - Nature

An Unusual Mutation Type Explains the Nature of Late-Life Balance Problems - University of Miami

Profiling complex repeat expansions in RFC1 in Parkinson’s disease - Nature

Long-read sequencing revealed complex biallelic pentanucleotide repeat expansions in RFC1 -related Parkinson’s disease - Nature

Latest research

Motor, Extrapyramidal, and Cognitive Involvement in RFC1 Disease: A Systematic Review and Meta-Analysis

Comprehensive neuropsychological assessment and FDG-PET imaging in patients with RFC1-related disorder

Neurogenic cough in CANVAS syndrome: objective cough monitoring reveals a distinctive clinical pattern

Vestibular assessment in definite cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS): A case of siblings study

Oculomotor abnormalities in patients with cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) reflect midline cerebellar impairment

Novel Clinical Insights From a Swedish RFC1 Spectrum Disorder Cohort

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures

Repeat Expansions in a Chilean Cohort with Adult-Onset Cerebellar Ataxia

Enhancing Cerebellar Findings with Positional Manoeuvres

Nerve ultrasound, neuronopathy and cough predict sensory neuropathy patients with RFC1 expansions

The Cerebellar Neuropsychiatric Rating Scale in the Spinocerebellar Ataxias

The Spectrum of Peripheral-Vestibular Deficits and Their Change Over Time in CANVAS/RFC1-Related Ataxia Systematic Review and Meta-Analysis of Quantitative Head-Impulse Testing

Videos

RFC1 ve CANVAS Hastalığı: Sebep, Prognoz, Tedavi ve Gelecek Yaklaşımlar

SÍNDROME DE CANVAS: La tríada de Ataxia, Tos y Genética que debes conocer

C.A.N.V.A.S

Life under
CANVAS.

Q&A: Fay Grant On Bringing Her Entrepreneur Spirit To Fighting RFC1-CANVAS - Forbes

Q&A: Fay Grant On Bringing Her Entrepreneur Spirit To Fighting RFC1-CANVAS - Forbes